Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …

Tyrosinase catalyzes the oxidation of phenols and catechols (o-diphenols) to o-quinones.
The reactivities of o-quinones thus generated are responsible for oxidative browning of plant …

Skin cancers are among the most common cancers worldwide and are increasingly
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …

Background: Currently, no consensus on the use of blood tests for monitoring disease
recurrence in patients with resected melanoma exists. The only meta-analysis conducted in …

Glutathione is an important antioxidant that plays a crucial role in the cellular protection
against oxidative stress and detoxification of electrophilic mutagens, and carcinogens …

Simple Summary This review provides an updated overview about molecular features,
clinical advancements and therapeutic directions of the primary mucosal melanoma which …

Opinion statement Because the recent success of novel therapeutic approaches has
dramatically changed the clinical management of melanoma, less invasive and repeatable …

Background and aims With the development of novel therapies for advanced malignant
melanoma (MM), biomarkers that can accurately reflect the progression of MM are needed …

Glutathione (GSH) is a ubiquitous tripeptide that is biosynthesized in situ at high
concentrations (1–5 mM) and involved in the regulation of cellular homeostasis via multiple …

Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient
mortality. However, current clinical and histological variables show limited accuracy in …