It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …

Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …

Abstract Background Circular RNAs (circRNAs) regulate various biological activities and
have been shown to play crucial roles in hepatocellular carcinoma (HCC) progression …

To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Background Hepatocellular carcinoma (HCC) is one of the most common malignancies
globally. Despite aggressive and multimodal treatment regimens, the overall survival of HCC …

The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …

Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a
serious, long-term threat to patients' health and life. Systemic chemotherapy remains the first …

Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

HCC comprises∼ 80% of primary liver cancer. HCC is the only major cancer for which death
rates have not improved over the last 10 years. Most patients are diagnosed with advanced …