Context The increase in thyroid screening in the general population may lead to earlier
detection of medullary thyroid carcinoma (MTC). Objective We aimed to evaluate secular …

Background. Medullary thyroid carcinoma (MTC) accounts for 1%–2% of thyroid cancer in
the United States based on the latest Surveillance, Epidemiology, and End Results (SEER) …

Background: Thyroid cancer (TC) has one of the fastest increasing incidences worldwide
and primarily involves papillary thyroid cancer (PTC). The BRAFV600E mutation is the most …

The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic
breast cancer is the first effective 'chemical therapy'proven in clinical trial to treat any cancer …

Purpose Marital status has emerged as an important influence on several cancer outcomes,
but its role in medullary thyroid cancer (MTC) remains unclear. This study was to explore the …

Background To prospectively evaluate the role of procalcitonin (PCT) in screening of
patients with thyroid nodules for medullary thyroid carcinoma (MTC). Materials and methods …

Surgical treatment of advanced thyroid malignancy can be morbid, compromising normal
functions of the upper aerodigestive tract. There is a paucity of guidelines dedicated to the …

Introduction Vandetanib has recently demonstrated clinically meaningful benefits in patients
with unresectable, locally advanced or metastatic medullary thyroid cancer (MTC). Given the …

Background: The cyclin-dependent-kinase inhibitors (CDKN)/retinoblastoma (RB1) pathway
has been implicated as having a role in medullary thyroid carcinoma (MTC) tumorigenesis …

Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour
that originates from the parafollicular C-cells of the thyroid gland. The RET proto-oncogene …