CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
LF Allen, J Sebolt-Leopold, MB Meyer - Seminars in oncology, 2003 - Elsevier
Several key growth factors, cytokines, and proto-oncogenes transduce their growth-and
differentiation-promoting signals through the mitogen-activated protein kinase or …
differentiation-promoting signals through the mitogen-activated protein kinase or …
Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria
and New Perspectives from Syste Page 1 Current Pharmaceutical Design, 2006, 12, 3161-3171 …
and New Perspectives from Syste Page 1 Current Pharmaceutical Design, 2006, 12, 3161-3171 …
Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells
SH Kim, CD Jun, K Suk, BJ Choi, H Lim… - Toxicological …, 2006 - academic.oup.com
The discovery of drugs for the treatment of inflammatory allergic diseases such as, asthma,
allergic rhinitis, and sinusitis is a very important subject in human health. Gallic acid (3, 4, 5 …
allergic rhinitis, and sinusitis is a very important subject in human health. Gallic acid (3, 4, 5 …
Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line
YD Min, CH Choi, H Bark, HY Son, HH Park, S Lee… - Inflammation …, 2007 - Springer
Objective and design: Mast cell-mediated allergic inflammation is involved in many diseases
such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro …
such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro …
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes
S Rodriguez-Enriquez, I Kim, RT Currin, JJ Lemasters - Autophagy, 2006 - Taylor & Francis
Mitochondria become targets for autophagic degradation after nutrient deprivation, a
process also termed mitophagy. In this study, we used LysoTracker Red (LTR) and …
process also termed mitophagy. In this study, we used LysoTracker Red (LTR) and …
5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase
S Giri, N Nath, B Smith, B Viollet, AK Singh… - Journal of …, 2004 - Soc Neuroscience
AMP-activated protein kinase (AMPK) is tightly regulated by the cellular AMP: ATP ratio and
plays a central role in the regulation of energy homeostasis and metabolic stress. A …
plays a central role in the regulation of energy homeostasis and metabolic stress. A …
Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-κB
A great number of people are suffering from allergic inflammatory diseases such as asthma,
atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these …
atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these …
Cellular mechanisms in sepsis
E Jean-Baptiste - Journal of intensive care medicine, 2007 - journals.sagepub.com
Mortality remains very high among septic patients despite the advanced treatments
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …
Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application
MJ Nell, GS Tjabringa, AR Wafelman, R Verrijk… - peptides, 2006 - Elsevier
New peptides for lipopolysaccharide (LPS) and lipoteichoic acid (LTA) neutralization in
upper respiratory tract infections were developed and evaluated in terms of efficacy and …
upper respiratory tract infections were developed and evaluated in terms of efficacy and …
Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases …
Z Rasheed, N Akhtar, AN Anbazhagan… - Journal of …, 2009 - Springer
Background Mast cells and basophils are multifunctional effector cells and contain plentiful
secretary granules in their cytoplasm. These cell types are involved in several inflammatory …
secretary granules in their cytoplasm. These cell types are involved in several inflammatory …