The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB),
funded by the United States National Science Foundation, National Institutes of Health, and …

T cells are critical for protective immune responses to pathogens and tumors. The T-cell
receptor (TCR)–CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …

Macromolecular protein assemblies are of fundamental importance for many processes
inside the cell, as they perform complex functions and constitute central hubs where …

Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …

Membrane nanoobjects are very important tools to study biomembrane properties. Two
types are described herein: Bicelles and Nanodiscs. Bicelles are obtained by thorough …

The nanodisc technology is increasingly used for structural studies on membrane proteins
and drug delivery. The development of synthetic polymer nanodiscs and the recent …

Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …