The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA
neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony …

There are currently more than 600 diseases characterized as affecting the central nervous
system (CNS) which inflict neural damage. Unfortunately, few of these conditions have …

MRI and histological studies have shown global alterations in iron levels in the brains of
patients with multiple sclerosis (MS), including increases in the iron stored by macrophages …

Alzheimer´ s disease (AD) is a neurodegenerative disorder with no known cure and rapid
rise in incidence. The predominant cognitive impairment is currently treated using cognitive …

In Alzheimer's disease (AD), different types of neurons and different brain areas show
differential patterns of vulnerability towards neurofibrillary degeneration, which provides the …

The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Recent findings show that parvalbumin (PV) interneuron function is impaired in Alzheimer's
disease (AD), and that this impairment in PV function can be linked to network dysfunction …