Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow
of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the …

Adult tissue-specific stem cells have the capacity to self-renew and generate functional
differentiated cells that replenish lost cells throughout an organism's lifetime. Studies on …

Although recent data suggests that osteoblasts play a key role within the hematopoietic stem
cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies …

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-
related protein that functions as a tumor suppressor. We found that merlin mediates contact …

OBJECTIVE: Hematopoietic stem and progenitor cells normally reside in the bone marrow
but can be mobilized into the peripheral blood following treatment with granulocyte colony …

The molecular events that regulate engraftment and mobilization of hematopoietic stem cells
and progenitors (HSC/Ps) are still incompletely defined,. We have examined the role of the …

Stem cells are characterized by their dual ability to reproduce themselves (self‐renew) and
specialize (differentiate), yielding a plethora of daughter cells that maintain and regenerate …

HEMATOPOIESIS IS A complex process in which pluripo-tent stem cells proliferate and
differentiate to generate the full complement of mature blood cells. More than 30 …

An efficient and practical ex vivo expansion methodology for human hematopoietic
stem/progenitor cells (HSPCs) is critical in realizing the potential of HSPC transplantation in …

The production of mature blood cells within the bone marrow (BM) is attributed to a pool of
haemopoietic stem cells (HSC). It is now evident that HSC reside preferentially at the …