G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …

CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Dear Editor, PD-L1 is a well-known transmembrane protein, which is highly expressed on
many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly …

Summary p62 is a well-characterized autophagy receptor that recognizes and sequesters
specific cargoes into autophagosomes for degradation. p62 promotes the assembly and …

Metformin, traditionally regarded as a hypoglycemic drug, has been studied in other various
fields including inflammation. The specific mechanism of metformin's effect on immune cells …

Double‐stranded DNA is recognized as a danger signal by cyclic guanosine
monophosphate‐adenosine monophosphate synthase (cGAS), triggering innate immune …

Cancer progression is an intricate biological process profiled by not only unscheduled
proliferation, but also altered metabolism mechanisms. In this article, we introduced a novel …

Protein palmitoylation, in which C16 fatty acid chains are attached to cysteine residues via a
reversible thioester linkage, is one of the most common lipid modifications and plays …

Antibodies targeting programmed cell death protein 1 (PD-1) or its ligand programmed
death-ligand 1 (PD-L1) are profoundly changing the methods to treat cancers with long-term …