Heat stress (HS) occurs when temperatures exceed a physiological range, overwhelming
compensatory mechanisms. Most mammalian testes are∼ 4–5° C cooler than core body …

Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …

The failure of testicular descent or cryptorchidism is the most common defect in newborn
boys. The descent of the testes during development is controlled by insulin-like 3 peptide …

The purpose of the study was to examine the occurrence of programmed cell death
(apoptosis) in normal and chromosomally aneuploid testis and ovaries during the second …

The vast majority of mammalian testes are located outside the body cavity for proper
thermoregulation. Heat has an adverse effect on mammalian spermatogenesis and …

Herein, we compare the different experimental regimes used to induce testicular heat stress
and summarise their impact on sperm production and male fertility. Irrespective of the …

During spermatogenesis, germ cells initially expand exponentially through mitoses. A
majority of these cells are then eliminated through p53-mediated apoptosis to maintain …

For normal spermatogenesis, the temperature of the scrotum is lower than that of the body.
The mechanism by which mammalian testes undergoes cell death as the result of exposure …

The detrimental effects of heat stress on fertility in cattle are less pronounced in heat-tolerant
breeds. Although these genetic differences reflect differences in thermoregulation, cells from …

Male germ cell apoptosis has been extensively explored in rodents. In contrast, very little is
known about the susceptibility of developing germ cells to apoptosis in response to busulfan …