Aberrant gene silencing is highly associated with altered cell cycle regulation during
carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which …

Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of
epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid …

The resistance of cancer cells to chemotherapeutic drugs greatly reduces the therapeutic
effect in cancer patients, and the toxic side effects caused by chemotherapy also seriously …

Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …

Epigallocatechin gallate (EGCG) is the main bioactive component of catechins
predominantly present in various types of tea. EGCG is well known for a wide spectrum of …

Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …

The growing interest in cancer epigenetics is largely due to the reversible nature of
epigenetic changes which tend to alter during the course of carcinogenesis. Major …

Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of
polyphenols, a class of natural products widely explored for a potential applicability for the …