A global review on short peptides: frontiers and perspectives

V Apostolopoulos, J Bojarska, TT Chai, S Elnagdy… - Molecules, 2021 - mdpi.com
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application

J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …

Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems

R Bajracharya, JG Song, BR Patil, SH Lee, HM Noh… - Drug Delivery, 2022 - Taylor & Francis
Conventional chemotherapy lacking target selectivity often leads to severe side effects,
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …

Immunoinformatics Design of Multi-Epitope Peptide-Based Vaccine Against Schistosoma mansoni Using Transmembrane Proteins as a Target

RCO Sanches, S Tiwari, LCG Ferreira… - Frontiers in …, 2021 - frontiersin.org
Schistosomiasis remains a serious health issue nowadays for an estimated one billion
people in 79 countries around the world. Great efforts have been made to identify good …

Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review

Y Zhang, P Guo, Z Ma, P Lu, D Kebebe… - Journal of …, 2021 - Springer
Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …

Cell penetrating peptides: the potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Developments in vaccine adjuvants

FZ Firdaus, M Skwarczynski, I Toth - Vaccine Design: Methods and …, 2022 - Springer
Vaccines, including subunit, recombinant, and conjugate vaccines, require the use of an
immunostimulator/adjuvant for maximum efficacy. Adjuvants not only enhance the strength …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

The role of cell‐penetrating peptides in potential anti‐cancer therapy

M Zhou, X Zou, K Cheng, S Zhong, Y Su… - Clinical and …, 2022 - Wiley Online Library
Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold

J Bojarska, A Mieczkowski, ZM Ziora, M Skwarczynski… - Biomolecules, 2021 - mdpi.com
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …