Stem cell homing: From physiology to therapeutics
JL Liesveld, N Sharma, OS Aljitawi - Stem Cells, 2020 - academic.oup.com
Stem cell homing is a multistep endogenous physiologic process that is also used by
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …
Mesenchymal stromal cells: current understanding and clinical status
HK Salem, C Thiemermann - Stem cells, 2010 - academic.oup.com
Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of
pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the …
pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the …
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
IG Winkler, V Barbier, B Nowlan, RN Jacobsen… - Nature medicine, 2012 - nature.com
The microenvironment, or niche, surrounding a stem cell largely governs its cellular fate.
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone …
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone …
Biology of hematopoietic stem cells and progenitors: implications for clinical application
M Kondo, AJ Wagers, MG Manz… - Annual review of …, 2003 - annualreviews.org
▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
The molecular pathways involved in the differentiation of hematopoietic progenitors are
unknown. Here we report that chemokine-mediated interactions of megakaryocyte …
unknown. Here we report that chemokine-mediated interactions of megakaryocyte …
Mechanisms that regulate the function of the selectins and their ligands
D Vestweber, JE Blanks - Physiological reviews, 1999 - journals.physiology.org
Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …
Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
The capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …
Neutrophil mobilization and clearance in the bone marrow
RC Furze, SM Rankin - Immunology, 2008 - Wiley Online Library
The bone marrow is the site of neutrophil production, a process that is regulated by the
cytokine granulocyte colony‐stimulating factor (G‐CSF). Mature neutrophils are continually …
cytokine granulocyte colony‐stimulating factor (G‐CSF). Mature neutrophils are continually …
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment …
Hematopoietic stem cell homing and engraftment require several adhesion interactions,
which are not fully understood. Engraftment of nonobese/severe combined …
which are not fully understood. Engraftment of nonobese/severe combined …
The bone marrow vascular niche: home of HSC differentiation and mobilization
The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated
sinusoidal vessels whose integrity is maintained and supported by surrounding …
sinusoidal vessels whose integrity is maintained and supported by surrounding …