Stem cell homing is a multistep endogenous physiologic process that is also used by
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …

Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of
pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the …

The microenvironment, or niche, surrounding a stem cell largely governs its cellular fate.
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone …

▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The
hematopoietic stem cell, the common ancestor of all types of blood cells, is one of the best …

The molecular pathways involved in the differentiation of hematopoietic progenitors are
unknown. Here we report that chemokine-mediated interactions of megakaryocyte …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

The capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic
compartment is vital to stem cell–based tissue engineering and other adoptive cellular …

The bone marrow is the site of neutrophil production, a process that is regulated by the
cytokine granulocyte colony‐stimulating factor (G‐CSF). Mature neutrophils are continually …

Hematopoietic stem cell homing and engraftment require several adhesion interactions,
which are not fully understood. Engraftment of nonobese/severe combined …

The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated
sinusoidal vessels whose integrity is maintained and supported by surrounding …