[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application

W Zuo, X Zhao - Clinical Immunology, 2021 - Elsevier
With the global spread of coronavirus disease 2019 (COVID-19), the important role of
natural killer (NK) cells in the control of various viral infections attracted more interest, via …

Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection

R Littera, L Chessa, S Deidda, G Angioni… - PloS One, 2021 - journals.plos.org
Background The diversity in the clinical course of COVID-19 has been related to differences
in innate and adaptative immune response mechanisms. Natural killer (NK) lymphocytes are …

NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals

A Cuapio, C Boulouis, I Filipovic, D Wullimann… - Molecular …, 2022 - Springer
Adaptive immune responses have been studied extensively in the course of mRNA
vaccination against COVID-19. Considerably fewer studies have assessed the effects on …

Natural killer cells in COVID-19: from infection, to vaccination and therapy

A Zafarani, MH Razizadeh, S Pashangzadeh… - Future …, 2023 - Taylor & Francis
Natural killer (NK) cells are among the most important innate immunity members, which are
the first cells that fight against infected cells. The function of these cells is impaired in …

HLA-C* 04: 01 affects HLA class I heterozygosity and predicted affinity to SARS-CoV-2 peptides, and in combination with age and sex of Armenian patients contributes …

A Hovhannisyan, V Madelian, S Avagyan… - Frontiers in …, 2022 - frontiersin.org
The novel SARS-CoV-2 coronavirus infection has become a global health concern, causing
the COVID-19 pandemic. The disease symptoms and outcomes depend on the host …

NK and T cell immunological signatures in hospitalized patients with COVID-19

L Bergantini, M d'Alessandro, P Cameli, D Cavallaro… - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome caused by coronavirus 2 emerged in Wuhan (China) in
December 2019 and has severely challenged the human population. NK and T cells are …

Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?

MH Razizadeh, A Zafarani… - Cell Communication and …, 2023 - Springer
Innate immunity is the first line of the host immune system to fight against infections. Natural
killer cells are the innate immunity lymphocytes responsible for fighting against virus …

[HTML][HTML] Unlocking therapeutic potential: Integration of drug repurposing and immunotherapy for various disease targeting

VA Pawar, A Tyagi, C Verma, KP Sharma… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Drug repurposing, also known as drug repositioning, entails the application of pre-approved
or formerly assessed drugs having potentially functional therapeutic amalgams for curing …

Safety and feasibility study of ex vivo expanded allogeneic-NK cells infusion in patients with acute pneumonia caused by COVID-19

M Ahmadvand, MS Barough, ZS Hashemi… - Pilot and Feasibility …, 2023 - Springer
Background NK cells are the most active innate immune cells in antiviral immunity, which
are impaired by SARS-COV2 infection. Infusion of allogeneic NK cells might be a …