Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

The significant role of topoisomerases in the control of DNA chain topology has been
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …

Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

Introduction Cancer has been identified as one of the leading causes of death worldwide.
The biological target of some anticancer agents is topoisomerase I, an enzyme involved in …

Leishmaniasis, one of the neglected diseases, ranks second to malaria in the cause of
parasitic mortality and morbidity. The present chemotherapeutic regimen faces the …

In this paper, we present a copper (I)-catalyzed nitrile-addition/N-arylation ring-closure
cascade for the synthesis of 5, 11-dihydro-6 H-indolo [3, 2-c] quinolin-6-ones from 2-(2 …

Natural products are widely used as source for drugs development. An interesting example
is represented by natural drugs developed against human topoisomerase IB, a ubiquitous …

R-loops are comprised of a DNA: RNA hybrid and a displaced single-strand DNA (ssDNA)
that reinvades the DNA duplex behind the moving RNA polymerase. Because they have …

DNA topoisomerase I was found to be highly abundant in fast-proliferating tumor cells and is
a potential target for anticancer therapy. A series of G-quadruplex-containing …

Topoisomerases are enzymes that play essential roles in DNA replication, transcription,
chromosome segregation, and recombination. All cells have two major forms of DNA …