Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …

Background Chronic non-communicable diseases (CNCD) represent a major cause of
morbidity and mortality. Type 2 diabetes mellitus (T2DM) is one of the most prevalent CNCD …

Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a
narrow range. Defects in the function and mass of β-cells play a significant role in the …

Human enteroviruses (EVs), including coxsackieviruses, the numbered enteroviruses, and
echoviruses, cause a wide range of diseases, such as hand, foot, and mouth disease …

For over a century, viruses have left a long trail of evidence implicating them as frequent
suspects in the development of type 1 diabetes. Through vigorous interrogation of viral …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …