Ion channels are crucial components of cellular excitability and are involved in many
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …

In less than a decade, a small family of channel-forming glycoproteins, named pannexins,
have captured the interest of many biologists, in large part due to their association with …

Pannexin-1 (Panx1) is a large-pore ion and solute permeable channel highly expressed in
the nervous system, where it subserves diverse processes, including neurite outgrowth …

The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …

Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …

The central nervous system (CNS) is composed of a highly heterogeneous population of
cells. Dynamic interactions between different compartments (neuronal, glial, and vascular …

Connexin hemichannels are single membrane channels which have been traditionally
thought to work in pairs to form gap junction channels across two opposing cells. In …

Tissue injury involves coordinated systemic responses including inflammatory response,
targeted cell migration, cell-cell communication, stem cell activation and proliferation, and …