The main protease of SARS-CoV-2 (called M pro or 3CL pro) is essential for processing
polyproteins encoded by viral RNA. Several M pro mutations were found in SARS-CoV-2 …

The main protease of SARS-CoV-2 (called Mpro or 3CLpro) is essential for processing
polyproteins encoded by viral RNA. Macromolecules adopt several favored conformations in …

Most natural proteins tend to be marginally stable, which allows them to gain flexibility for
biological functions. However, marginal stability is often associated with protein misfolding …

Computational coarse-grained models play a fundamental role as a research tool in protein
folding, and they are important in bridging theory and experiments. Folding mechanisms are …

Choroid plexus carcinomas (CPCs) are rare pediatric tumors often associated with Li-
Fraumeni Syndrome (LFS). In LFS, TP53 mutations are involved. A germline mutation in the …

A comunidade científica já se utiliza da combinação de técnicas experimentais e
computacionais em suas investigações, especialmente para sistemas biológicos complexos …

This study was aimed at improving the thermostability of dextran glucosidase PspAG97A, a
member of the glycoside hydrolase family 97, from Pseudoalteromonas sp. K8. A total of 9 …

Nas últimas décadas, as proteínas têm sido alvo de grande interesse industrial. As funções
que tais moléculas desempenham têm demonstrado utilidade nas mais variadas áreas …