In recent years, high-throughput sequencing technologies provide unprecedented
opportunity to depict cancer samples at multiple molecular levels. The integration and …

Background DNA methylation can regulate the role of long noncoding RNAs (lncRNAs) in
the development of lung adenocarcinoma (LUAD). The present study aimed to identify …

The prognoses of patients with pancreatic adenocarcinoma (PAAD) remain poor due to the
lack of biomarkers for early diagnosis and effective prognosis prediction. RNA sequencing …

Background: Collagen type 1 alpha 1 chain (COL1A1) is an extracellular matrix protein
comprising two alpha 1 chains and one alpha 2 chain. Our previous study identified that …

Background Lung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid
structures (TLS) are ectopic lymphoid organs with similar morphological and molecular …

MicroRNAs (miRNAs) that are mutually modulated by their interacting partners (interactome)
are being increasingly noted for their significant role in pathogenesis and treatment of …

Combining omics data from different layers using integrative methods provides a better
understanding of the biology of a complex disease such as cancer. The discovery of …

Lung adenocarcinoma (LUAD) is caused by multiple biological factors. Therefore, it will be
more meaningful to study the prognosis from the perspective of omics integration. Given the …

Many studies have shown that the hyperactivation of ribosome biogenesis plays essential
roles in the initiation and progression of cancers. As a ribosome assembly factor, PNO1 …

The unprecedented proliferation of recent large-scale and multi-omics databases of cancers
has given us many new insights into genomic and epigenomic deregulation in cancer …