Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism …

Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One …

Biochemistry textbooks and cell culture experiments seem to be telling us two different
things about the significance of external glutamine supply for mammalian cell growth and …

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for
many fundamental cell functions in cancer cells, including synthesis of metabolites that …

Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …

Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as
a promising target for cancer therapy. However, efforts to drug this process are confounded …