Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …

Introduction Platelets play a key role in arterial thrombosis and antiplatelet therapy is pivotal
in the treatment of cardiovascular disease. Current antiplatelet drugs target different …

Background: The coronavirus disease 2019 (COVID-19) pandemic has rapidly spread
around the world, and the lack of effective treatment has fueled a global search for the …

Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) infection, is a severe acute respiratory syndrome with an …

abstract Timely and effective antithrombotic therapy is critical to improving outcome,
including survival, in patients with acute coronary syndrome (ACS). Achieving effective …

Background Late antibody-mediated rejection (ABMR) triggered by donor-specific
antibodies (DSA) is a cardinal cause of kidney allograft dysfunction and loss. Diagnostic …

Background: Our study aims to perform a meta-analysis of benefits and risks associated with
the use of non-vitamin K oral anticoagulants (NOAC) versus vitamin K antagonists (VKA) in …

Antiplatelet therapy with P2Y12 receptor inhibitors (clopidogrel, prasugrel, ticagrelor,
cangrelor) is a cornerstone of medical therapy after percutaneous coronary interventions …

Severe COVID-19 is associated with the dynamic changes in coagulation parameters.
Coagulopathy is considered as a major extra-pulmonary risk factor for severity and mortality …

Background Obesity is considered to be a major comorbidity. Obese patients suffer from an
increased proinflammatory state associated with a premature aging phenotype including …