The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

INTRODUCTION An intricate balance with our intestinal microbes is pivotal to human health.
A key interface of host-microbial interactions occurs in the mucus that covers the intestinal …

A number of mechanisms ensure that the intestine is protected from pathogens and also
against our own intestinal microbiota. The outermost of these is the secreted mucus, which …

Objective The colonic inner mucus layer protects us from pathogens and commensal-
induced inflammation, and has been shown to be defective in active UC. The aim of this …

Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative
colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing …

Metabolic syndrome is manifested by visceral obesity, hypertension, glucose intolerance,
hyperinsulinism, and dyslipidemia. According to the CDC, metabolic syndrome in the US …

Background & Aims One of the features of ulcerative colitis (UC) is a defect in the protective
mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it …

Objective Epidemiological and clinical data indicate that patients suffering from IBD with
long-standing colitis display a higher risk to develop colorectal high-grade dysplasia …

Epithelial transport is a multifaceted process crucial for maintaining normal physiological
functions in the human body. This comprehensive review delves into the pathophysiological …