Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …

After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have
gained a detailed knowledge of the cells involved, specific recognition mechanisms and …

Research over the past decade has revealed the increasingly complex biologic features of
the CD4+ T-cell lineage. This T-cell subset, which was originally defined on the basis of …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

We used a suppressor-cell assay to study a possible mechanism of allergy desensitization.
Before specific immunotherapy, blood mononuclear cells from 20 patients with ragweed …

For over 35 years, immunologists have divided T-helper (TH) cells into functional subsets. T-
helper type 1 (TH1) cells—long thought to mediate tissue damage—might be involved in the …

Recent advances in cancer immunotherapy have directly built on 50 years of fundamental
and technological advances that made checkpoint blockade and T cell engineering …

Although immune-based therapy is proving to be a success in several cancer types, only a
set of patients appear to respond to immune checkpoint blockade including PD-1 and CTLA …

The authors focus on a specific biomedical platform known as immunophenotyping. They
describe its emergence as an experimental system with roots in biology (immunology) and …

Background: The Internet has become an established source for health information. The
number of individuals using the Internet to search for health information, ranging from …