Autophagy and apoptosis cascade: which is more prominent in neuronal death?

R Gupta, RK Ambasta, P Kumar - Cellular and molecular life sciences, 2021 - Springer
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Recent trends in the application of nanoparticles in cancer therapy: The involvement of oxidative stress

M Sanati, AR Afshari, P Kesharwani… - Journal of Controlled …, 2022 - Elsevier
In the biomedical area, the interdisciplinary field of nanotechnology has the potential to bring
numerous unique applications, including better tactics for cancer detection, diagnosis, and …

Apelin-13 suppresses neuroinflammation against cognitive deficit in a streptozotocin-induced rat model of Alzheimer's disease through activation of BDNF-TrkB …

H Luo, Y Xiang, X Qu, H Liu, C Liu, G Li… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …

The cellular model for Alzheimer's disease research: PC12 cells

D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

Activation of Nrf2 signaling by sitagliptin and quercetin combination against β‐amyloid induced Alzheimer's disease in rats

Y Li, Q Tian, Z Li, M Dang, Y Lin… - Drug development …, 2019 - Wiley Online Library
The objective of this study was to evaluate the neuroprotective effect of sitagliptin (Sita),
quercetin (QCR) and its combination in β‐amyloid (Aβ) induced Alzheimer's disease (AD) …

Exploring the bi‐directional relationship between autophagy and Alzheimer's disease

H Kuang, CY Tan, HZ Tian, LH Liu… - CNS neuroscience & …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is characterized by β‐amyloid (Aβ) deposition and Tau
phosphorylation, in which its pathogenesis has not been cleared so far. The metabolism of …

Physical exercise-induced myokines in neurodegenerative diseases

B Lee, M Shin, Y Park, SY Won, KS Cho - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders …

Apelin/APJ system: an emerging therapeutic target for neurological diseases

A Li, Q Zhao, L Chen, Z Li - Molecular Biology Reports, 2023 - Springer
Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively
expressed in various systems, especially the nervous system. This article reviews the role of …

[HTML][HTML] Cellular responses and functions of α7 nicotinic acetylcholine receptor activation in the brain: A narrative review

ZQ Xu, WJ Zhang, DF Su, GQ Zhang… - Annals of translational …, 2021 - ncbi.nlm.nih.gov
The α7 nicotinic acetylcholine receptor (α7nAChR) has been studied for many years since
its discovery. Although many functions and characteristics of brain α7nAChR are widely …

Neuroprotective gain of Apelin/APJ system

JX Zhou, NN Shuai, B Wang, X Jin, X Kuang, SW Tian - Neuropeptides, 2021 - Elsevier
Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many
studies have shown that the apelin/APJ system has neuroprotective properties, such as anti …