Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements

P Kolimi, S Narala, D Nyavanandi, AAA Youssef… - Cells, 2022 - mdpi.com
Wound healing is highly specialized dynamic multiple phase process for the repair of
damaged/injured tissues through an intricate mechanism. Any failure in the normal wound …

Macrophage-mediated inflammation in skin wound healing

A Hassanshahi, M Moradzad, S Ghalamkari, M Fadaei… - Cells, 2022 - mdpi.com
Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

Mesenchymal stem cell-derived exosomes loaded with miR-155 inhibitor ameliorate diabetic wound healing

P Gondaliya, AA Sayyed, P Bhat, M Mali… - Molecular …, 2022 - ACS Publications
Diabetic wounds are one of the debilitating complications that affect up to 20% of diabetic
patients. Despite the advent of extensive therapies, the recovery rate is unsatisfactory, and …

The impact of prolonged inflammation on wound healing

JCJ Holzer-Geissler, S Schwingenschuh, M Zacharias… - Biomedicines, 2022 - mdpi.com
The treatment of chronic wounds still challenges modern medicine because of these
wounds' heterogenic pathophysiology. Processes such as inflammation, ischemia and …

Surfactin-reinforced gelatin methacrylate hydrogel accelerates diabetic wound healing by regulating the macrophage polarization and promoting angiogenesis

L Yan, K Han, B Pang, H Jin, X Zhao, X Xu… - Chemical Engineering …, 2021 - Elsevier
Chronic wound healing is a severe complication that threatens the life of diabetic patients
because of the damaged skin microvasculature and prolonged inflammation at the wound …

The role of microRNA in the inflammatory response of wound healing

Y Jiang, X Xu, L Xiao, L Wang, S Qiang - Frontiers in Immunology, 2022 - frontiersin.org
Wound healing, a highly complex pathophysiological response to injury, includes four
overlapping phases of hemostasis, inflammation, proliferation, and remodeling. Initiation …

Regenerative approaches for chronic wounds

F Berthiaume, HC Hsia - Annual Review of Biomedical …, 2022 - annualreviews.org
Chronic skin wounds are commonly found in older individuals who have impaired circulation
due to diabetes or are immobilized due to physical disability. Chronic wounds pose a severe …

[HTML][HTML] Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment

MG Monaghan, R Borah, C Thomsen… - Advanced Drug Delivery …, 2023 - Elsevier
Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have
debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress …

Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction

S Yang, Y Li, C Liu, Y Wu, Z Wan… - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetes mellitus is a common systematic chronic disease amongst dental patients. The
elevated glucose microenvironment can prolong the healing of tooth extraction sockets …

[HTML][HTML] Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing

JP Yadav, A Verma, P Pathak, AR Dwivedi… - Biomedicine & …, 2024 - Elsevier
The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process,
contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation …