ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …

Chronic diseases are the leading cause of death worldwide with increasing prevalence in all
age groups, genders, and ethnicities. Most chronic disease deaths occur in middle-to low …

Much evidence shows that physical exercise (PE) is a strong gene modulator that induces
structural and functional changes in the brain, determining enormous benefit on both …

Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …

Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Hippocampal volume increase in response to aerobic exercise has been consistently
observed in animal models. However, the evidence from human studies is equivocal. We …

Cognitive deficits are pervasive among people with schizophrenia and treatment options are
limited. There has been an increased interest in the neurocognitive benefits of exercise, but …

Exergaming, or active video gaming, has become an emerging trend in fitness, education
and health sectors. It is defined as digital games that require bodily movements to play …