Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it
is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in …

Background: Preeclampsia is a syndrome of high blood pressure (BP) with end organ
damage in late pregnancy that is associated with high circulating soluble VEGF receptor …

Background: We studied the ability of the nonsteroidal MR (mineralocorticoid receptor)
antagonist finerenone to attenuate vascular remodeling and pulmonary hypertension using …

Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs)
are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with …

This paper attempts to explain how the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) virus causes the complications that make coronavirus disease 2019 (COVID …

Diabetes mellitus induces a pathophysiological disorder known as diabetic cardiomyopathy
and may eventually cause heart failure. Diabetic cardiomyopathy is manifested with systolic …

Arteries make up a major part of the circulatory system, with the veins and heart being the
other main components. Arteries make up tubelike structures that are responsible for the …

After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR)
in the vasculature, the advent of technology to specifically knockout the MR from smooth …

Introduction. Abnormal proliferation of vascular smooth muscle cells (VSMCs) can cause
various vascular diseases, such as atherosclerosis, restenosis, and pulmonary …