Cell death is an important component of the pathophysiology of cardiovascular disease. An
understanding of how cardiomyocytes die, and why regeneration of cells in the heart is …

Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione …

Tumor cell intrinsic ferroptosis-initiating mechanisms are unknown. Here, we discover that T
cell-derived interferon (IFN) γ in combination with arachidonic acid (AA) induces …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

Dysregulation of fatty acid metabolism is recognized as a component of malignant
transformation in many different cancers, including breast; yet the potential for targeting this …

Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid
peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of …

The activation of long-chain free fatty acids is the first step reaction of their usage in the cells
and tissues, which are catalyzed by a family of enzymes called acyl-coenzyme A …

The mechanisms that promote an inflammatory environment and accelerated
atherosclerosis in diabetes are poorly understood. We show that macrophages isolated from …

The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health.
Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs …