Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses
worldwide which impairs the social functioning of the afflicted patients. Astrocytes promote …

With the umbrella term 'neurodevelopmental disorders'(NDDs) we refer to a plethora of
congenital pathological conditions generally connected with cognitive, social behavior, and …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Adenosine compartmentalization has a profound impact on immune cell function by
regulating adenosine localization and, therefore, extracellular signaling capabilities, which …

Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Pathogenesis and salugenesis are the first and second stages of the two-stage problem of
disease production and health recovery. Salugenesis is the automatic, evolutionarily …

Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …

Adenosine receptors (ARs) have been identified as promising therapeutic targets for
countless pathological conditions, spanning from inflammatory diseases to central nervous …

Purines and purinergic receptors are widely distributed throughout the human body. Purine
molecules within cells play crucial roles in regulating energy metabolism and other cellular …

Our modern society suffers from both pervasive sleep loss and substance abuse—what may
be the indications for sleep on substance use disorders (SUDs), and could sleep contribute …