Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …

Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …

The gut-brain axis is gaining more attention in neurodevelopmental disorders, especially
autism spectrum disorder (ASD). Many factors can influence microbiota in early life …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

After over 30 years of research, the development of HDAC inhibitors led to five FDA/Chinese
FDA-approved drugs and many others under clinical or preclinical investigation to treat …

Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD‑
1)/programmed death ligand 1 (PD‑L1) axis have achieved marked and durable efficacy in …

Introduction Histone deacetylase (HDAC) inhibitors have been considered as an attractive
strategy to reverse aberrant epigenetic changes associated with cancer treatments. The use …

In recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a
research hotspot. The development of generic targeted nanotherapeutics might bring new …