Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout
the brain and spinal cord. It regulates various actions and consciousness linked to a variety …

Abstract Alzheimer's disease (AD), the most prominent form of dementia in the elderly, has
no cure. Strategies focused on the reduction of amyloid beta or hyperphosphorylated Tau …

Background Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric
symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP) …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma
has enabled the use of blood tests to measure Alzheimer's disease (AD) biomarker …

Neural dynamics are shaped and constrained by the projections of a small nucleus in the
pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain's violin, activity in …

Increased astrocytic Ca 2+ signaling has been shown in Alzheimer's disease mouse
models, but to date no reports have characterized behaviorally induced astrocytic Ca 2+ …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …