Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Nutrients and oxidative stress: friend or foe?

BL Tan, ME Norhaizan… - Oxidative medicine and …, 2018 - Wiley Online Library
There are different types of nutritionally mediated oxidative stress sources that trigger
inflammation. Much information indicates that high intakes of macronutrients can promote …

Neuropathy and diabetic foot syndrome

M Volmer-Thole, R Lobmann - International journal of molecular sciences, 2016 - mdpi.com
Diabetic foot ulceration is a serious complication of diabetes mellitus worldwide and the
most common cause of hospitalization in diabetic patients. The etiology of diabetic foot …

NF-κβ: a potential target in the management of vascular complications of diabetes

SV Suryavanshi, YA Kulkarni - Frontiers in pharmacology, 2017 - frontiersin.org
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ
plays key role in pathogenesis of vascular complications of diabetes. Persistent …

[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Mechanisms of diabetic foot ulceration: A review

H Deng, B Li, Q Shen, C Zhang, L Kuang… - Journal of …, 2023 - Wiley Online Library
Diabetic foot ulcers (DFUs) are associated with complex pathogenic factors and are
considered a serious complication of diabetes. The potential mechanisms underlying DFUs …

Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy

PGS Makker, SS Duffy, JG Lees, CJ Perera, RS Tonkin… - PloS one, 2017 - journals.plos.org
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …

Gastroprotective effect of sinapic acid on ethanol-induced gastric ulcers in rats: involvement of Nrf2/HO-1 and NF-κB signaling and antiapoptotic role

M Raish, M Shahid, YA Bin Jardan… - Frontiers in …, 2021 - frontiersin.org
Background: In the current study, we evaluated the therapeutic potential of sinapic acid (SA)
in terms of the mechanism underlying its gastroprotective action against ethanol-induced …

Cerebral ischemic damage in diabetes: an inflammatory perspective

V Shukla, AK Shakya, MA Perez-Pinzon… - Journal of …, 2017 - Springer
Stroke is one of the leading causes of death worldwide. A strong inflammatory response
characterized by activation and release of cytokines, chemokines, adhesion molecules, and …

The macrophage: a key player in the pathophysiology of peripheral neuropathies

Z Msheik, M El Massry, A Rovini, F Billet… - Journal of …, 2022 - Springer
Macrophages are present in all mammalian tissues and coexist with various cell types in
order to respond to different environmental cues. However, the role of these cells has been …