Background Riluzole is approved for the treatment of amyotrophic lateral sclerosis in most
countries. Questions persist about its clinical utility because of high cost and modest efficacy …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Background Riluzole is the only drug to prolong survival for amyotrophic lateral sclerosis
(ALS) and, at a dose of 100 mg, was associated with a 35% reduction in mortality in a …

The amygdala is a limbic brain region that plays a key role in emotional processing,
neuropsychiatric disorders, and the emotional‐affective dimension of pain. Preclinical and …

Consulta preanestésica Una sala de pre-anestesia por área quirúrgica Salas de
recuperación postanestésica susceptible de recibir pacientes de quirófanos contiguos …

Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

Multiple sclerosis is one of the most common causes of chronic neurological disability
beginning in early to middle adult life. Multiple sclerosis is idiopathic in nature, yet …

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

There are currently no effective pharmacological agents available to stop or prevent the
progression of Huntington's disease (HD), a rare hereditary neurodegenerative disorder. In …