[HTML][HTML] What is a cell type and how to define it?

H Zeng - Cell, 2022 - cell.com
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Insights into Alzheimer's disease from single-cell genomic approaches

MH Murdock, LH Tsai - Nature neuroscience, 2023 - nature.com
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Molecularly defined and spatially resolved cell atlas of the whole mouse brain

M Zhang, X Pan, W Jung, AR Halpern, SW Eichhorn… - Nature, 2023 - nature.com
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

The emergence and influence of internal states

SW Flavell, N Gogolla, M Lovett-Barron, M Zelikowsky - Neuron, 2022 - cell.com
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses

SM O'Toole, HK Oyibo, GB Keller - Neuron, 2023 - cell.com
Predictive processing postulates the existence of prediction error neurons in cortex. Neurons
with both negative and positive prediction error response properties have been identified in …

Spatial omics technologies at multimodal and single cell/subcellular level

J Park, J Kim, T Lewy, CM Rice, O Elemento… - Genome Biology, 2022 - Springer
Spatial omics technologies enable a deeper understanding of cellular organizations and
interactions within a tissue of interest. These assays can identify specific compartments or …

Cortical somatostatin interneuron subtypes form cell-type-specific circuits

SJ Wu, E Sevier, D Dwivedi, GA Saldi, A Hairston, S Yu… - Neuron, 2023 - cell.com
The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …

Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research

HE Park, SH Jo, RH Lee, CP Macks, T Ku… - Advanced …, 2023 - Wiley Online Library
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …

Multimodal mapping of cell types and projections in the central nucleus of the amygdala

Y Wang, S Krabbe, M Eddison, FE Henry, G Fleishman… - Elife, 2023 - elifesciences.org
The central nucleus of the amygdala (CEA) is a brain region that integrates external and
internal sensory information and executes innate and adaptive behaviors through distinct …

Mapping visual functions onto molecular cell types in the mouse superior colliculus

Y Liu, EL Savier, VJ DePiero, C Chen, DC Schwalbe… - Neuron, 2023 - cell.com
The superficial superior colliculus (sSC) carries out diverse roles in visual processing and
behaviors, but how these functions are delegated among collicular neurons remains …