CRISPR/Cas9-Mediated Genome Editing in Cancer Therapy
The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …
[HTML][HTML] Natural-source Payloads used in the conjugated drugs architecture for cancer therapy: Recent advances and future directions
C Li, K Shi, S Zhao, J Liu, Q Zhai, X Hou, J Xu… - Pharmacological …, 2024 - Elsevier
Drug conjugates are obtained from tumor-located vectors connected to cytotoxic agents via
linkers, which are designed to deliver hyper-toxic payloads directly to targeted cancer cells …
linkers, which are designed to deliver hyper-toxic payloads directly to targeted cancer cells …
Unveiling Gene Interactions in Alzheimer's Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach
Alzheimer's Disease (AD) is a complex disease and the leading cause of dementia in older
people. We aimed to uncover aspects of AD's pathogenesis that may contribute to drug …
people. We aimed to uncover aspects of AD's pathogenesis that may contribute to drug …
CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia
N Tirado, MJ Mansilla, A Martinez-Moreno, J Alcain… - bioRxiv, 2024 - biorxiv.org
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by
high rates of induction failure and relapse, and effective targeted immunotherapies are …
high rates of induction failure and relapse, and effective targeted immunotherapies are …
Transcriptional control of leukemogenesis by the chromatin reader SGF29
Aberrant expression of stem cell–associated genes is a common feature in acute myeloid
leukemia (AML) and is linked to leukemic self-renewal and therapy resistance. Using AF10 …
leukemia (AML) and is linked to leukemic self-renewal and therapy resistance. Using AF10 …
Genome-Wide Association Study of Histopathological Quantification Methods in Primary Age-Related Tauopathy
BM Babrowicz - 2024 - search.proquest.com
Alzheimer's disease (AD) is characterized by beta-amyloid (Aß) plaques and
hyperphosphorylated tau containing neurofibrillary tangles (NFTs) throughout the brain. In …
hyperphosphorylated tau containing neurofibrillary tangles (NFTs) throughout the brain. In …
Characterization of ADAM10 as a vulnerability and novel potential therapy target of acute leukemia
JP Schmid - 2024 - edoc.ub.uni-muenchen.de
The interaction of leukemic cells with their surrounding bone marrow (BM) microenvironment
is crucial for leukemia formation and maintenance. Especially dormant leukemia stem cells …
is crucial for leukemia formation and maintenance. Especially dormant leukemia stem cells …
The Effects of CRISPR Cas 9 on Leukemia Treatment
S Majdi, Y Alilou - International Journal of BioLife Sciences (IJBLS), 2024 - jobiost.com
Background and Aim: Leukemia is a group of blood malignancies marked by uncontrolled
cell growth in bone marrow and blood, disrupting immune function. Treatment has …
cell growth in bone marrow and blood, disrupting immune function. Treatment has …