How long do rapid diagnostic tests remain positive after anti-malarial treatment?
Abstract Background Rapid diagnostic tests (RDTs) are increasingly becoming a paradigm
for both clinical diagnosis of malaria infections and for estimating community parasite …
for both clinical diagnosis of malaria infections and for estimating community parasite …
Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
C O'Brien, PP Henrich, N Passi… - Current opinion in …, 2011 - journals.lww.com
Should ACTs fail, no suitable alternatives exist as first-line treatments of P. falciparum
malaria. Intensified efforts are essential to monitor the spread of resistance, define …
malaria. Intensified efforts are essential to monitor the spread of resistance, define …
Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label …
R Leang, WRJ Taylor, DM Bouth, L Song… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Western Cambodia is recognized as the epicenter of Plasmodium falciparum multidrug
resistance. Recent reports of the efficacy of dihydroartemisinin (DHA)-piperaquine (PP), the …
resistance. Recent reports of the efficacy of dihydroartemisinin (DHA)-piperaquine (PP), the …
Artemisinin resistance–modelling the potential human and economic costs
Background Artemisinin combination therapy is recommended as first-line treatment for
falciparum malaria across the endemic world and is increasingly relied upon for treating …
falciparum malaria across the endemic world and is increasingly relied upon for treating …
Malaria parasite-synthesized heme is essential in the mosquito and liver stages and complements host heme in the blood stages of infection
Heme metabolism is central to malaria parasite biology. The parasite acquires heme from
host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free …
host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free …
Selection and spread of artemisinin-resistant alleles in Thailand prior to the global artemisinin resistance containment campaign
E Talundzic, SA Okoth, K Congpuong… - PLoS …, 2015 - journals.plos.org
The recent emergence of artemisinin resistance in the Greater Mekong Subregion poses a
major threat to the global effort to control malaria. Tracking the spread and evolution of …
major threat to the global effort to control malaria. Tracking the spread and evolution of …
PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport
GM Gomez, G D'Arrigo, CP Sanchez, F Berger… - PLoS …, 2023 - journals.plos.org
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of
quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug …
quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug …
Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis
Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …
Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania
MA Kakolwa, MK Mahende, DS Ishengoma… - Malaria journal, 2018 - Springer
Background Artemisinin-based combination therapy (ACT) is the first-line anti-malarial
treatment of uncomplicated malaria in most malaria endemic countries, including Tanzania …
treatment of uncomplicated malaria in most malaria endemic countries, including Tanzania …
A theoretical examination of the relative importance of evolution management and drug development for managing resistance
NS McClure, T Day - Proceedings of the Royal Society B …, 2014 - royalsocietypublishing.org
Drug resistance is a serious public health problem that threatens to thwart our ability to treat
many infectious diseases. Repeatedly, the introduction of new drugs has been followed by …
many infectious diseases. Repeatedly, the introduction of new drugs has been followed by …