Loss of hepatic fructose-1, 6-bisphosphate aldolase B (Aldob) leads to a paradoxical up-
regulation of glucose metabolism to favor hepatocellular carcinogenesis (HCC), but the …

High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer
subtype. PARP inhibitors (PARPi) have become the mainstay of HGSC-targeted therapy …

The transcription cycle of RNA polymerase II (RNAPII) is governed at multiple points by
opposing actions of cyclin-dependent kinases (CDKs) and protein phosphatases, in a …

Primary prostate cancer is generally treatable by androgen deprivation therapy, however,
later recurrences of castrate-resistant prostate cancer (CRPC) that are more difficult to treat …

Protein phosphorylation is a ubiquitous cellular process that allows for the nuanced and
reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a heterotrimeric …

Therapies targeting tyrosine and serine/threonine kinases have raised enormous interest as
potential cure for cancer patients in many common cancer types. However, except for the …

PP2A is a highly conserved eukaryotic serine/threonine protein phosphatase of the PPP
family of phosphatases with fundamental cellular functions. In cells, PP2A targets specific …

Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer
agents based on their capacity to stabilize P53. Regardless of this activity, USP7 inhibitors …

Over the last decade, the use of targeted therapies has immensely increased in the
treatment of cancer. However, treatment for endometrial carcinomas (ECs) has lagged …

Background Fibroblasts have important roles in the synthesis and remodeling of
extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal …