Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein
kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase inhibitors …

Maintenance of genome integrity is fundamental for cellular physiology. Our hereditary
information encoded in the DNA is intrinsically susceptible to suffer variations, mostly due to …

Background Fibroblasts have important roles in the synthesis and remodeling of
extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal …

Phosphoprotein phosphatases are of growing interest in the pathophysiology of many
diseases and are often the neglected partner of protein kinases. One family member, PP2A …

Although tyrosine kinase inhibitors (TKIs) have demonstrated significant efficacy in
advanced lung adenocarcinoma (LUAD) patients with pathogenic alterations in EGFR, most …

The c-MYC (MYC) oncoprotein is often overexpressed in human breast cancer; however, its
role in driving disease phenotypes is poorly understood. Here, we investigate the role of …

Osteosarcoma is the most common malignant bone tumor in children and adolescents with
high rate of incidence, high frequency of recurrence, and high degree of metastasis. This …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited and,
very often, ineffective medical and surgical therapeutic options. The treatment of patients …

The tumor suppressor protein phosphatase 2A (PP2A) is a serine/threonine phosphatase
whose activity is inhibited in most human cancers. One of the best-characterized PP2A …

The neuronal microtubule‐associated protein tau serves a critical role in regulating axonal
microtubule dynamics to support neuronal and synaptic functions. Furthermore, it contributes …