Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical
roles in normal development, tissue homeostasis and immunity, and its disturbed regulation …

Apoptotic cells are commonly observed in a broad range of tissues during mammalian
embryonic and fetal development. Specific requirements and functions of programmed cell …

Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Bax and Bak, two functionally similar, pro-apoptotic proteins of the Bcl-2 family, are known
as the gateway to apoptosis because of their requisite roles as effectors of mitochondrial …

Bcl‐2 family members are the arbiters of mitochondrial apoptotic pathway, which is
conserved through evolution. The stoichiometry of pro‐versus antiapoptotic Bcl‐2 family …

Increasing evidence indicates that microRNAs (miRNAs) may be critical players in
spermatogenesis. The miRNA expression profiles of THY1+-enriched undifferentiated …