Members of the Bcl-2 family include pro-and antiapoptotic proteins that regulate
programmed cell death of developing tissues and death in response to cellular damage. In …

One of the most important roles of apoptosis is the maintenance of tissue homeostasis.
Impairment of apoptosis leads to a number of pathological conditions. In response to …

The importin (IMP) superfamily of nuclear transport proteins is essential to key
developmental pathways, including in the murine testis where expression of the 6 distinct …

Germ cell apoptosis have been recognized as an important event in order to regulate daily
sperm production in humans and in animal models as well. Several studies in rat, mouse …

Mammalian cells infected with human adenoviruses (Ads) undergo an apoptotic response
as a result of expression of the viral E1A proteins, and this process is suppressed by the viral …

The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit
either a pro-death or pro-survival function. Gene knockout studies revealed that different pro …

Spermatogonia-stem cells and progenitors of adult spermatogenesis-are killed through a
p53-regulated apoptotic process after γ-irradiation but the death effectors are still poorly …

Testicular apoptosis is involved in the regulation of germ cell numbers, allowing optimal
sperm production. Apoptosis has been described to occur in response to the absence of …

Genetic recombination during B-cell development regularly results in the generation of
autoreactive, potentially pathogenic B-cell receptors (BCRs). Consequently, multiple …

Abstract Purpose Undescended Testes (UDT) are prevalent in 2%–5% of male infants and
cause malignancy and infertility. During germ cell development, abnormal gonocytes usually …