Reactive oxygen species (ROS) are molecules involved in signal transduction pathways
with both beneficial and detrimental effects on human cells. ROS are generated by many …

Myocardial protection against ischemia/reperfusion injury (IRI) is mediated by various
ligands, activating different cellular signaling cascades. These include classical cytosolic …

The equilibrium solubility of 3-methyl-6-nitroindazole in co-solvent mixtures of acetonitrile
(1)+ water (2), ethanol (1)+ water (2) and n-propanol (1)+ water (2) is reported. Experiments …

As transcriptional co-activators, Yes-associated protein (YAP) and transcriptional coactivator
with PDZ-binding motif (TAZ) can regulate cell proliferation, migration, differentiation, and …

Cancer patients have an increased risk of cardiovascular disease and, notably, a significant
prevalence of acute coronary syndrome (ACS). It has been shown that an elevated presence …

Improvements in early detection and treatment of gynecologic malignancies have led to an
increasing number of survivors who are at risk of long-term cardiac complications from …

Cancer patients are at risk for both venous and arterial thrombotic events. Accumulating
evidence suggests a link between cancer and arterial thrombosis events. The …

Introduction Vascular endothelial growth factor (VEGF) is a key target in cancer therapy.
However, cardiovascular safety has been one of the most challenging aspects of anti …

ABSTRACT Background Cardiac adverse events (AEs) are common in tyrosine kinase
inhibitors (TKIs). This study explored the cardiac AEs of TKIs through the Food and Drug …

Background: Pazopanib (PAZ) is an oral angiogenesis inhibitor approved to treat soft tissue
sarcoma (STS) but associated with a large interpatient pharmacokinetic (PK) variability and …