The main transporter for biotin is sodium dependent multivitamin transporter (SMVT), which
is overexpressed in various aggressive cancer cell lines such as ovarian (OV 2008, ID8) …

Clostridial binary toxins (Clostridium perfringens Iota toxin, Clostridium difficile transferase,
Clostridium spiroforme toxin, Clostridium botulinum C2 toxin) as Bacillus binary toxins …

The binary Clostridium botulinum C2 toxin consists of the binding/translocation component
C2IIa and the separate enzyme component C2I. C2IIa delivers C2I into the cytosol of …

To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane
traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides …

Botulinum neurotoxin (BoNT), a Category A biodefense agent, delivers a protease to motor
neuron cytosol that cleaves one or more soluble NSF attachment protein receptors (SNARE) …

Binary toxins are produced by several pathogenic bacteria. Examples are the C2 toxin from
Clostridium botulinum, the iota toxin from Clostridium perfringens, and the CDT from …

The uses of botulinum toxin in the fields of neurology, ophthalmology, urology, rehabilitation
medicine and aesthetic applications have been revolutionary for the treatment of patients …

We have previously generated a recombinant C2-streptavidin fusion protein for the delivery
of biotin-labeled molecules of low molecular weight into the cytosol of mammalian cells. A …

Versatile nanocarrier systems facilitating uptake of exogenous proteins are highly alluring in
evaluating these proteins for therapeutic applications. The self‐assembly of an efficient nano …

The digestive tract is one of the ecosystems that harbors the largest number and greatest
variety of bacteria. Among them, certain bacteria have developed various strategies …