Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …

Abstract Vitamin B 12 (B12; also known as cobalamin) is a B vitamin that has an important
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …

Organic acidurias are inherited metabolic diseases due to the deficiency of an enzyme or a
transport protein involved in one of the several cellular metabolic pathways devoted to the …

The inorganic chemistry of the cobalt corrinoids, derivatives of vitamin B 12, is reviewed, with
particular emphasis on equilibrium constants for, and kinetics of, their axial ligand …

S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced
de novo via the methionine cycle. The demethylation of SAM produces S …

B12‐antimetabolites are compounds that counteract the physiological effects of vitamin B12
and related natural cobalamins. Presented here is a structure‐and reactivity‐based concept …

Members of the genus Leptospirillum are aerobic iron-oxidizing bacteria belonging to the
phylum Nitrospira. They are important members of microbial communities that catalyze the …

The role of nitric oxide in the pathogenesis and progression of neurodegenerative illnesses
such as Parkinson's and Alzheimer's diseases has become prominent over the years …

The molecular mechanisms that underlie the neurological manifestations of patients with
inherited diseases of vitamin B12 (cobalamin) metabolism remain to date obscure. We …

Inborn errors of metabolism (IEMs) are a group of monogenic disorders characterized by
dysregulation of the metabolic networks that underlie development and homeostasis …