[HTML][HTML] Three-dimensional modelling of ovarian cancer: From cell lines to organoids for discovery and personalized medicine

C Yee, KA Dickson, MN Muntasir, Y Ma… - … in Bioengineering and …, 2022 - frontiersin.org
Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

Designer self‐assembling peptide hydrogels to engineer 3D cell microenvironments for cell constructs formation and precise oncology remodeling in ovarian cancer

Z Yang, H Xu, X Zhao - Advanced Science, 2020 - Wiley Online Library
Designer self‐assembling peptides form the entangled nanofiber networks in hydrogels by
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …

[HTML][HTML] Applications of 3D printing in tumor treatment

J Li, D Liang, X Chen, W Sun, X Shen - Biomedical Technology, 2024 - Elsevier
As an emerging technology relevant to materials science, 3D printing technology simplifies
material production process, shortens the preparation cycle, and provides a broader space …

Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips

J Radhakrishnan, S Varadaraj, SK Dash, A Sharma… - Drug Discovery …, 2020 - Elsevier
Highlights•3D cultures are more advantageous than monolayers as biomimetics for drug
screening.•Bioprinting constructs complex tissue models that serve in vitro drug …

[HTML][HTML] Drug resistance evaluation in novel 3D in vitro model

M Nowacka, K Sterzynska, M Andrzejewska… - Biomedicine & …, 2021 - Elsevier
Ovarian cancer rates the highest mortality among all gynecological malignancies. The main
reason for high mortality is the development of drug resistance. It can be related to changes …

Metastatic voyage of ovarian cancer cells in ascites with the assistance of various cellular components

K Uno, S Iyoshi, M Yoshihara, K Kitami, K Mogi… - International Journal of …, 2022 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique
metastatic route using ascites, known as the transcoelomic root. However, studies on ascites …

Three-dimensional 3D culture models in gynecological and breast cancer research

YM Salinas-Vera, J Valdes, Y Perez-Navarro… - Frontiers in …, 2022 - frontiersin.org
Traditional two-dimensional (2D) monolayer cell cultures have long been the gold standard
for cancer biology research. However, their ability to accurately reflect the molecular …

Effect of Polyplex Size on Penetration into Tumor Spheroids

C Casadidio, JEM Hartman, BS Mesquita… - Molecular …, 2023 - ACS Publications
Ovarian cancer is one of the most lethal gynecological cancers in the world. In recent years,
nucleic acid (NA)-based formulations have been shown to be promising treatments for …

Exploring cancer cell behavior in vitro in three-dimensional multicellular bioprintable collagen-based hydrogels

DF Duarte Campos, A Bonnin Marquez, C O'Seanain… - Cancers, 2019 - mdpi.com
In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor
growth, invasion, and drug delivery. The 3D spheroid model of solid tumors has been the …

A comparative analysis of 2D and 3D experimental data for the identification of the parameters of computational models

M Cortesi, D Liu, C Yee, DJ Marsh, CE Ford - Scientific Reports, 2023 - nature.com
Computational models are becoming an increasingly valuable tool in biomedical research.
Their accuracy and effectiveness, however, rely on the identification of suitable parameters …