Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges

S Bloch, KM Holleran, TL Kash, EM Vazey, JA Rinker… - Alcohol, 2022 - Elsevier
Alcohol use disorder (AUD) is frequently comorbid with mood disorders, and these co-
occurring neuropsychiatric disorders contribute to the development and maintenance of …

Using deep learning to study emotional behavior in rodent models

JY Kuo, AJ Denman, NJ Beacher… - Frontiers in Behavioral …, 2022 - frontiersin.org
Quantifying emotional aspects of animal behavior (eg, anxiety, social interactions, reward,
and stress responses) is a major focus of neuroscience research. Because manual scoring …

[HTML][HTML] The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females

ME Castle, ME Flanigan - Neurobiology of Stress, 2024 - Elsevier
Abstract Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide,
but current treatments are insufficient in fully addressing the symptoms that often lead to …

Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience

NL Goodwin, JJ Choong, S Hwang, K Pitts… - Nature …, 2024 - nature.com
The study of complex behaviors is often challenging when using manual annotation due to
the absence of quantifiable behavioral definitions and the subjective nature of behavioral …

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking

CS Wilkinson, HL Blount, S Davis, G Rojas, L Wu… - Scientific Reports, 2023 - nature.com
Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we
assessed whether co-consumption of oxycodone and alcohol influence the intake of one …

Tongue− Brain‐Transported ZnO Nanoparticles Induce Abnormal Taste Perception

A Chen, R Wang, Y Kang, J Liu, J Wu… - Advanced …, 2023 - Wiley Online Library
Nanoparticles (NPs) can be transported to the brain, especially through nerves, because of
their small size and high biological activity. Previous studies confirmed that zinc oxide (ZnO) …

Impact and role of hypothalamic corticotropin releasing hormone neurons in withdrawal from chronic alcohol consumption in female and male mice

S Neira, S Lee, LA Hassanein, T Sides… - Journal of …, 2023 - Soc Neuroscience
Worldwide, alcohol use and abuse are a leading risk of mortality, causing 5.3% of all deaths.
The endocrine stress system, initiated by the peripheral release of corticotropin releasing …

Escalating caffeine dose-dependently increases alcohol consumption in adult male, but not female, C57BL/6J mice

BN Swanson, SA Lewis, A Kaur, JN Berry - … Biochemistry and Behavior, 2024 - Elsevier
Although previous research has illustrated the effects of the consumption of alcohol and
caffeine individually, less research has focused on the popular combination of the two drugs …

All Hands on Deck: We Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis

ML Bedard, AC Nowlan… - ACS chemical …, 2023 - ACS Publications
Opioid use disorder (OUD) affects millions of people throughout the United States, yet there
are only three Food and Drug Administration-approved pharmacological treatments. Though …

Adolescent intermittent ethanol exposure alters adult exploratory and affective behaviors, and cerebellar Grin2b expression in C57BL/6J mice

K Healey, RC Waters, SG Knight, GM Wandling… - Drug and Alcohol …, 2023 - Elsevier
Binge drinking is one of the most common patterns (more than 90%) of alcohol consumption
by young people. During adolescence, the brain undergoes maturational changes that …