In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

At present, the clinical strategies for treating chronic wounds are limited, especially when it
comes to pain relief and rapid wound healing. Therefore, there is an urgent need to develop …

The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …

Neutrophils promptly accumulate in large numbers at sites of tissue injury. Injuries to the skin
or mucosae disrupt barriers against the external environment, and the bactericidal actions of …

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a
non-uniform phenotype and diverse functional activities. Both tumor-associated …

Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

There are well-established links between acute inflammation and successful tissue repair
across evolution. Innate immune reactions contribute significantly to pathogen clearance …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …