Understanding the diversity of membrane lipid composition
T Harayama, H Riezman - Nature reviews Molecular cell biology, 2018 - nature.com
Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …
Metabolites as regulators of insulin sensitivity and metabolism
Q Yang, A Vijayakumar, BB Kahn - Nature reviews Molecular cell …, 2018 - nature.com
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells
AN Nabhan, DG Brownfield, PB Harbury, MA Krasnow… - Science, 2018 - science.org
Alveoli, the lung's respiratory units, are tiny sacs where oxygen enters the bloodstream. They
are lined by flat alveolar type 1 (AT1) cells, which mediate gas exchange, and AT2 cells …
are lined by flat alveolar type 1 (AT1) cells, which mediate gas exchange, and AT2 cells …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
[HTML][HTML] The diversity and breadth of cancer cell fatty acid metabolism
Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
[HTML][HTML] Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
R Bertolio, F Napoletano, M Mano… - Nature …, 2019 - nature.com
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …
Homocysteine modification in protein structure/function and human disease
H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …
[PDF][PDF] Modification of proteins by metabolites in immunity
C Diskin, TAJ Ryan, LAJ O'neill - Immunity, 2021 - cell.com
Immunometabolism has emerged as a key focus for immunologists, with metabolic change
in immune cells becoming as important a determinant for specific immune effector …
in immune cells becoming as important a determinant for specific immune effector …
A not-so-ancient grease history: click chemistry and protein lipid modifications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …
The lipid basis of cell death and autophagy
Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …
biological functions. These lipids act as vital structural components of cell membranes …