Protein myristoylation is a C14 fatty acid modification found in all living organisms.
Myristoylation tags either the N-terminal alpha groups of cysteine or glycine residues …

Shigella flexneri, an intracellular Gram-negative bacterium causative for shigellosis,
employs a type III secretion system to deliver virulence effectors into host cells. One such …

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2
diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous …

Heat shock proteins (HSPs) constitute a large family of conserved proteins acting as
molecular chaperones that play a key role in intracellular protein homeostasis, regulation of …

Cells depend on hugely diverse lipidomes for many functions. The actions and structural
integrity of the plasma membrane and most organelles also critically depend on membranes …

One of the first molecular events in neurodegenerative diseases, regardless of etiology, is
protein mislocalization. Protein mislocalization in neurons is often linked to proteostasis …

Glutathione peroxidase‐like enzymes (GPXLs) constitute a family of eight peroxidases in
Arabidopsis thaliana. In contrast to the eponymous selenocysteine glutathione peroxidases …

The membrane-associated protein CD36, now officially designated as SR-B2, is present in
various tissues and fulfills multiple cellular functions. In heart and muscle, CD36 is the main …

Phosphorous-containing molecules are essential constituents of all living cells. While the
phosphate functional group is very common in small molecule natural products, nucleic …

Covalent attachment of C16: 0 to proteins (palmitoylation) regulates protein function.
Proteins are also S-acylated by other fatty acids including C18: 0. Whether protein acylation …