The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

Endothelial dysfunction is involved in the development of atherosclerosis, which precedes
asymptomatic structural vascular alterations as well as clinical manifestations of …

It is widely accepted that regular physical activity is beneficial for cardiovascular health.
Frequent exercise is robustly associated with a decrease in cardiovascular mortality as well …

Despite strong scientific evidence supporting the benefits of regular exercise for the
prevention and management of cardiovascular disease (CVD), physical inactivity is highly …

There is a pandemic of physical inactivity that appears to parallel the widespread
prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise …

In the last two decades evidence has gradually accumulated suggesting that the eye may be
a unique window for cardiovascular risk stratification based on the assessment of subclinical …

IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

Exercise based cardiac rehabilitation (CR) is recognized internationally as a class 1 clinical
practice recommendation for patients with select cardiovascular diseases and heart failure …