Given that obesity and diabetes have been major public health concerns and that disease
morbidities have been rising continuously, effective treatment for these diseases is urgently …

Multiple sclerosis, a condition characterised by demyelination and axonal damage in the
central nervous system, is due to autoreactive immune cells that recognise myelin antigens …

BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts
differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation …

Abstract Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group
(PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in …

The aberrant expression of methyltransferase Set7/9 plays a role in various diseases.
However, the contribution of Set7/9 in ischemic stroke remains unclear. Here, we show …

Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal
cells. Histone methylation is controlled by multiple lysine demethylases and is an important …

Macrophages undergo different cellular states upon activation that can be hyporesponsive
(tolerated) or hyperresponsive (primed or trained) to subsequent stimuli. Epigenetic …

Background and Objectives To investigate the total circular RNA (circRNA) profile in patients
with relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HCs). Methods …

Dysregulation of polycomb group (PcG) proteins that mediate epigenetic gene silencing
contributes to tumorigenesis. As core components of the polycomb repressive complex 1 …

Skeletal development and bone formation are regulated by epigenetic mechanisms that
either repress or enhance osteogenic commitment of mesenchymal stromal/stem cells and …