Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …

Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of
signal transduction and biological processes such as cell proliferation, apoptosis …

Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

Simple Summary Mitochondria play a crucial role in numerous cellular processes, including
energy production, apoptosis, and calcium homeostasis. In the male reproductive system …

Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the
efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma …

Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's
expression in most immune cells, either at baseline or upon activation, reflects its …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Intrinsic resistance of unknown mechanism impedes the clinical utility of inhibitors of cyclin-
dependent kinases 4 and 6 (CDK4/6i) in malignancies other than breast cancer. Here, we …